Drug interactions and the problem with default settings
At some hospitals, pantoprazole is not on the formulary. So, when a patient takes clopidogrel and pantoprazole, the drugs are automatically switched to clopidogrel and omeprazole. For a proton pump inhibitor (PPI), the default is omeprazole.
The Medical Letter, the FDA and UK’s National Guidelines for Stroke recommend if patients take clopidogrel and need a PPI, avoid omeprazole and use pantoprazole instead. The concern is …