MKSAP: 53-year-old man with right-sided facial weakness

Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.

A 53-year-old man is evaluated for persistent right-sided facial weakness. Three months ago, he first noticed “droopiness” of the right side of his lower face, difficulty closing the right eye and wrinkling the forehead, increased sensitivity to loud noises, and occasional slurred speech. Bell palsy was diagnosed, and he began a 10-day course of prednisone. He has noted only limited improvement, with continued facial drooping and mildly dysarthric speech; he now uses an eye patch over his right eye at night. The patient takes no medication.

On physical examination, vital signs are normal. Right-sided facial weakness involving the forehead, orbicularis oculi, and lower facial muscles is noted. Taste recognition is impaired on the anterior right side of the tongue. Facial sensation and the muscles of mastication are intact. The corneal reflex is present bilaterally, and the jaw reflex is normal. Hearing is intact bilaterally, as are extraocular reflexes, motor and sensory function, and deep tendon reflexes.

Which of the following is the most appropriate next step in management?

A: Acyclovir
B: Clinical observation
C: MRI of the brain
D: Physical therapy

MKSAP Answer and Critique

The correct answer is C: MRI of the brain.

An MRI of the brain should be obtained in this patient who has limited recovery despite appropriate treatment 3 months after onset of complete facial nerve (cranial nerve VII) palsy to rule out an underlying structural abnormality. He has acute weakness involving both upper and lower facial muscles, which favors a peripheral rather than central weakness. The initial presence of hyperacusis and the impaired taste noted on examination are also consistent with facial nerve involvement. In patients with typical isolated facial nerve paralysis, immediate brain imaging is unnecessary. Most of these patients have idiopathic Bell palsy, and 70% to 90% achieve complete recovery within 3 months. Severe residual weakness occurs in a minority of patients with Bell palsy, but the persistence of significant deficits at 3 months should prompt further investigation, including evaluation for alternative causes of facial nerve paralysis (such as diabetes mellitus, Lyme disease, vasculitis, HIV infection, sarcoidosis, paraproteinemia, and Sjögren syndrome) and an MRI of the brain to rule out structural causes. If results of this evaluation do not reveal a cause of the persistent symptoms, the diagnosis is incomplete recovery after Bell palsy, and clinical monitoring is then recommended.

Acute monotherapy with antiviral medications, such as acyclovir, does not improve prognosis. Early adjunctive use of antiviral therapy in addition to prednisone is favored by some experts, but the evidence supporting this treatment is inconsistent.

Evidence supporting the benefit of physical therapy for rehabilitation after facial nerve palsy is insufficient. In this patient, a structural cause of the deficits should first be excluded.

Key Point

  • MRI of the brain is an appropriate next step in management for patients with incomplete recovery 3 months after onset of facial nerve palsy despite appropriate initial treatment.

This content is excerpted from MKSAP 17 with permission from the American College of Physicians (ACP). Use is restricted in the same manner as that defined in the MKSAP 16 Digital license agreement. This material should never be used as a substitute for clinical judgment and does not represent an official position of ACP. All content is licensed to on an “AS IS” basis without any warranty of any nature. The publisher, ACP, shall not be liable for any damage or loss of any kind arising out of or resulting from use of content, regardless of whether such liability is based in tort, contract or otherwise.

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