The C-reactive protein is less than helpful in heart disease. “Screening for heart disease by measuring levels of C-reactive protein does not provide enough useful information to make the highly touted screening test worthwhile, a new study concludes.”

Here are my previous comments on this test:

Still not enough data to support general screening. There are some organizations that do recommend CRP screening. However, there are a couple of concerning issues:
i) CRP is not specific enough. Most inflammatory disorders cause CRP to rise.
ii) There is no therapy targeted to CRP, and there is insufficient data supporting that lowering CRP alone leads to a decrease in cardiovascular mortality.

At this time, I do not routinely order a CRP because of these reasons.