Skip to content
  • About
  • Contact
  • Contribute
  • Book
  • Careers
  • Podcast
  • Recommended
  • Speaking
  • All
  • Physician
  • Practice
  • Policy
  • Finance
  • Conditions
  • .edu
  • Patient
  • Meds
  • Tech
  • Social
  • Video
    • All
    • Physician
    • Practice
    • Policy
    • Finance
    • Conditions
    • .edu
    • Patient
    • Meds
    • Tech
    • Social
    • Video
    • About
    • Contact
    • Contribute
    • Book
    • Careers
    • Podcast
    • Recommended
    • Speaking

Learn about Clostridium difficile infection with a Medcomic

Jorge Muniz, PA-C
Conditions
January 8, 2018
420 Shares
Share
Tweet
Share

Clostridium difficile is a gram-positive anaerobic bacillus which secretes toxins (A and B) that cause diarrhea and pseudomembranous colitis. C. difficile is the most common infectious cause of nosocomial diarrhea. Transmission of C. difficile can occur from contact with contaminated humans and fomites. The organism contains endospores that can survive the acidity of the stomach and reach the large intestine.

C. difficile colonizes the intestinal tract after the normal gut flora has been altered by antibiotic therapy. It can flourish after any antibiotic therapy, but most notably occurs with broad-spectrum antibiotics such as clindamycin, cephalosporins, ampicillin, amoxicillin, and fluoroquinolones. Pseudomembranous colitis is an inflammatory bowel disorder in which yellowish plaques form over the damaged intestinal mucosa. The plaque is an exudate that resembles a membrane, hence the term “pseudomembranous.”

The signs and symptoms include fever, crampy abdominal pain, and diarrhea. Progression of the condition can lead to leukocytosis, dehydration, and toxic megacolon. The diagnosis is confirmed with a stool assay for C. difficile toxin. Pseudomembranes can be seen on sigmoidoscopy.

Treatment includes discontinuing the causative agent. Oral metronidazole is the treatment of choice in patients that do not respond to conservative measures. Alternatively, very severe cases may require oral vancomycin. Rarely, cases complicated by toxic megacolon or perforation may require total colectomy.

Jorge Muniz is an internal medicine physician assistant, illustrator, and author of Medcomic: The Most Entertaining Way to Study Medicine.

Image credit: Medcomic.com

Prev

Expanding coverage and cutting health care costs: ideas for 2018

January 8, 2018 Kevin 5
…
Next

A physician's love-hate relationship with dividends. And what he does about it.

January 9, 2018 Kevin 0
…

Tagged as: Gastroenterology, Infectious Disease

Post navigation

< Previous Post
Expanding coverage and cutting health care costs: ideas for 2018
Next Post >
A physician's love-hate relationship with dividends. And what he does about it.

More by Jorge Muniz, PA-C

  • Learn typical community acquired pneumonia with a Medcomic

    Jorge Muniz, PA-C
  • Learn about Salter-Harris fractures with a Medcomic

    Jorge Muniz, PA-C
  • Learn pulmonary hypertension with a Medcomic

    Jorge Muniz, PA-C

Related Posts

  • What medicine can learn from a poem

    Thomas L. Amburn
  • Structure case conferences as a primary way to teach and learn

    Robert Centor, MD
  • What medical students can learn from astronauts

    Denzil Mathew
  • What health reform can learn from United Airlines

    Brian C. Joondeph, MD
  • Residents need to learn medicine, not how to pass a test

    Eric W. Toth, DO
  • It’s time to learn the basics of financial management in medical school

    Aashish Shah

More in Conditions

  • Communication, power dynamics, and organizational culture in health care

    Beth Boynton, RN, MS, CP
  • Everyday dangers unknowingly impacting our health

    Tami Burdick
  • A shop teacher’s daughter on transforming patient safety

    Barbara L. Olson, RN
  • What happened to the chemical pathologist?

    Martin C. Young, MD
  • Second chances and simple beauty in thrift stores

    Debbie Moore-Black, RN
  • Air quality alert: Reducing our carbon footprint in health care

    Shreya Aggarwal, MD
  • Most Popular

  • Past Week

    • The erosion of patient care

      Laura de la Torre, MD | Physician
    • Challenging the diagnosis: dehydration or bias?

      Sydney Lou Bonnick, MD | Physician
    • COVID-19 unleashed an ongoing crisis of delirium in hospitals

      Christina Reppas-Rindlisbacher, MD, Nathan Stall, MD, and Paula Rochon, MD | Conditions
    • Air quality alert: Reducing our carbon footprint in health care

      Shreya Aggarwal, MD | Conditions
    • A teenager’s perspective: the pressing need for mental health days in schools

      Ruhi Saldanha | Conditions
    • Physician return-to-work policies

      Deepak Gupta, MD | Physician
  • Past 6 Months

    • Medical gaslighting: a growing challenge in today’s medical landscape

      Tami Burdick | Conditions
    • I want to be a doctor who can provide care for women: What states must I rule out for my medical education?

      Nandini Erodula | Education
    • Balancing opioid medication in chronic pain

      L. Joseph Parker, MD | Conditions
    • The erosion of patient care

      Laura de la Torre, MD | Physician
    • Reigniting after burnout: 3 physician stories

      Kim Downey, PT | Physician
    • Mourning the silent epidemic: the physician suicide crisis and suggestions for change

      Amna Shabbir, MD | Physician
  • Recent Posts

    • Physician return-to-work policies

      Deepak Gupta, MD | Physician
    • Communication, power dynamics, and organizational culture in health care

      Beth Boynton, RN, MS, CP | Conditions
    • How my patients’ Zoom backgrounds made me a better doctor

      Joseph Barrera, MD | Physician
    • Understanding reproductive rights: complex considerations

      Anonymous | Physician
    • Innovations in surgical education [PODCAST]

      The Podcast by KevinMD | Podcast
    • Everyday dangers unknowingly impacting our health

      Tami Burdick | Conditions

Subscribe to KevinMD and never miss a story!

Get free updates delivered free to your inbox.


Find jobs at
Careers by KevinMD.com

Search thousands of physician, PA, NP, and CRNA jobs now.

Learn more

Leave a Comment

Founded in 2004 by Kevin Pho, MD, KevinMD.com is the web’s leading platform where physicians, advanced practitioners, nurses, medical students, and patients share their insight and tell their stories.

Social

  • Like on Facebook
  • Follow on Twitter
  • Connect on Linkedin
  • Subscribe on Youtube
  • Instagram

CME Spotlights

From MedPage Today

Latest News

  • COVID Vax in Pregnancy Protects Young Infants Against Omicron
  • Repeat Tests for Inflammation Aid Prognosis After Acute Heart Failure
  • FDA OKs Another Injectable for Rare Kidney Disorder
  • Loneliness Tied to Subsequent Parkinson's Risk
  • A Promising New Approach to Reducing Burnout and Workforce Depletion

Meeting Coverage

  • Hot Flashes: Precursor to Alzheimer's Disease?
  • SABR Offers New Hope for Older Patients With Inoperable Kidney Cancer
  • Menopausal Women With Obesity Endure Worse Symptoms, Less HT Relief
  • Study Pinpoints Growing Use of Cannabis to Manage Menopause Symptoms
  • Fezolinetant Benefits Women Not Suited for Hormone Therapy
  • Most Popular

  • Past Week

    • The erosion of patient care

      Laura de la Torre, MD | Physician
    • Challenging the diagnosis: dehydration or bias?

      Sydney Lou Bonnick, MD | Physician
    • COVID-19 unleashed an ongoing crisis of delirium in hospitals

      Christina Reppas-Rindlisbacher, MD, Nathan Stall, MD, and Paula Rochon, MD | Conditions
    • Air quality alert: Reducing our carbon footprint in health care

      Shreya Aggarwal, MD | Conditions
    • A teenager’s perspective: the pressing need for mental health days in schools

      Ruhi Saldanha | Conditions
    • Physician return-to-work policies

      Deepak Gupta, MD | Physician
  • Past 6 Months

    • Medical gaslighting: a growing challenge in today’s medical landscape

      Tami Burdick | Conditions
    • I want to be a doctor who can provide care for women: What states must I rule out for my medical education?

      Nandini Erodula | Education
    • Balancing opioid medication in chronic pain

      L. Joseph Parker, MD | Conditions
    • The erosion of patient care

      Laura de la Torre, MD | Physician
    • Reigniting after burnout: 3 physician stories

      Kim Downey, PT | Physician
    • Mourning the silent epidemic: the physician suicide crisis and suggestions for change

      Amna Shabbir, MD | Physician
  • Recent Posts

    • Physician return-to-work policies

      Deepak Gupta, MD | Physician
    • Communication, power dynamics, and organizational culture in health care

      Beth Boynton, RN, MS, CP | Conditions
    • How my patients’ Zoom backgrounds made me a better doctor

      Joseph Barrera, MD | Physician
    • Understanding reproductive rights: complex considerations

      Anonymous | Physician
    • Innovations in surgical education [PODCAST]

      The Podcast by KevinMD | Podcast
    • Everyday dangers unknowingly impacting our health

      Tami Burdick | Conditions

MedPage Today Professional

An Everyday Health Property Medpage Today
  • Terms of Use | Disclaimer
  • Privacy Policy
  • DMCA Policy
All Content © KevinMD, LLC
Site by Outthink Group

Leave a Comment

Comments are moderated before they are published. Please read the comment policy.

Loading Comments...