Under current guidelines from the American Stroke Association, tissue plasminogen activator (tPA, commonly known as a "clot buster" drug) should be administered within 3-4.5 hours of “last seen normal” – and 1 hour of patient arrival – to potentially ameliorate a new onset stroke. ("Last seen normal" means exactly what it says. A patient who went to bet at 10 PM and awoke with slurred speech at 6 AM was ...
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