The statin debate ignores the signal of lifestyle as medicine

I rather doubt you need me to bring the roiling statin debate to your attention, given its prominence in scientific circles and mass media alike. In essence, a new set of guidelines for the use of lipid-lowering drugs to prevent heart disease was issued with considerable fanfare and then set off a firestorm of controversy. The old approach relied heavily on levels of LDL cholesterol, while the new approach relies on a calculation of overall cardiac risk that leaves LDL out of the mix altogether. At stake are statin prescriptions for millions of us.

So, as a physician specializing in preventive medicine, and with a long-standing interest in cardiac risk modification specifically, it makes sense for me to weigh in here. Perhaps some of my faithful readers — and my thanks for that, by the way — have been waiting for my verdict. So here you go: The answer may not matter a lot, because it’s the wrong question.

I guess it’s only fair to note that I have held back from entering this fray for two reasons, one lesser and one greater. The lesser reason is that we really don’t yet know the right answer. If it were truly clear exactly what criteria for statin use were best, there would be no controversy in the first place. There appear to be strengths and weaknesses to both sets of criteria, the old and the new. Either way, it’s clear that statins –which in fact are rather good drugs – can and do save lives when prescribed judiciously. The debate is all about what “judiciously” really means, and what is most judicious.

Frankly, I don’t think anyone knows for sure yet. To know with genuine certainty, we would need to randomize thousands of people to statin prescription by the old method, and thousands more to statin prescription by the new method, and see which group had less heart disease and premature death over time. Until or unless that is done — don’t hold your breath — we have competing expert opinions with no clear basis in empirical evidence to declare a winner.

As noted, that is the lesser reason for my apparent abdication. The greater reason is that I think it’s the wrong question. The right question is: How can a society look on passively at a situation that invites tens of millions of its citizens (no matter what criteria are used) to take a drug to fix what feet and forks could fix better, at lower cost, more universally, and absent the risk of side effects?

Statins really are good drugs, and under the conditions that now prevail, they do indeed save lives. And yes, alas, tens of millions of us are candidates for them. But such conditions need not prevail, and should not prevail. Why do we let them prevail?

As far as I’m concerned, the entire debate about statins is part of our societal static. It’s a background noise of cultural misdirection that favors the conflated interests of Big Food and Big Pharma while ignoring the compelling, consistent, signal of what lifestyle as medicine could do for us all.

We could prevent all those heart attacks, and more, without putting statins in the drinking water. We could add years to life, and life to years, and save rather than spend money doing it – if lifestyle were our preferred medicine. The signal has been there for literal decades that minimally 80 percent of all heart disease could be eliminated by lifestyle means readily at our disposal. There is a case that, but for rare anomalies, heart disease as we know it could be virtually eradicated by those same lifestyle means. And the same lifestyle medicine that could do this job would slash our risk for every other bad outcome as well, while enhancing energy, cultivating vitality, and contributing to overall quality of life. And unlike our statins, we could share these benefits with those we love.

But for the most part, we as individuals, and collectively as a culture, seem deaf to this signal. We watch our peers and parents succumb to heart disease, and wring our hands. We fret over the same fate overtaking us. We get prescriptions for drugs we wish we didn’t have to take, worry about serious side effects, suffer through minor ones, grumble about copays, and implicate ourselves in the unmanageable burden of “health” care costs.

And so our debate about statins, seemingly so important, plays out in the static of the status quo. No matter who wins the debate about statin indications, we the people — the tens of millions of people who, either way, are missing the signal and will wind up taking drugs to fix what lifestyle could fix better — lose.

David L. Katz is the founding director, Yale-Griffin Prevention Research Center. He is the author of Disease-Proof: The Remarkable Truth About What Makes Us Well.

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  • Margalit Gur-Arie

    Signals are difficult to discern when the ratio of signal to noise is systematically and purposely minimized in order to increase the ratio of dollars to investment.
    We have a food industry run amok, all the way from gigantic farm operations to the preparation and retail of stuff that looks and tastes edible, but it really isn’t, coupled with addiction R&D and insidious psyops style marketing to people from the day they are born until the day they die. The noise from this segment drowns the eating healthy signal by orders of magnitude.
    Then we have labor and effort saving technology engaged in deafening noise creation (and real poverty too), which silences the physical activity signal.
    Then we have the “health” industry, with its diet and wellness products stepping in to capitalize on the damage inflicted by the other two, and finally pharma makes the final sweep.
    It’s almost like one is manufacturing customers for the other and vice versa. Just to add insult to injury, the same giant international corporations own both the garbage food products and the “cure”. For example Weight Watchers was owned by Heinz until it was sold to some nondescript private equity group, Slimfast is owned by Unilever which also owns an array of mayonnaise and ice cream producers, and in the reformed future of health care, purveyors of Twinkies, beer and smokes are also prescribing and dispensing statins.

    There surely is a signal here, but it’s not the one of “personal responsibility”.

    • Margalit Gur-Arie

      …and if you have 20 minutes to spare, here is a fascinating account spanning 50 years of how the sugar and food industry systematically silenced our “signals”, effectively causing our health care crisis…

    • SarahJ89

      It’s not really “as if” one is manufacturing customers for the other. It’s actually what’s going on.

      The fact is, nothing will change as long as the rewards of health care are based on illness instead of health. God knows, the non-material rewards of medicine for which I suspect were the reasons many doctors embarked upon their profession are mostly gone.

  • John C. Key MD

    Thank you Dr, Katz…we needed an MD to speak up for lifestyle changes. I’ve halfway been expecting the statin-industrial complex to next want them added to the public water supply.

  • Dinah

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