Creatine causing muscle cramps and how supplements may be dangerous

About a month ago, a 44-year-old insurance executive came to see me with complaints of headaches and muscle cramps. His pain was caused by the typical cluster headache located behind one eye, accompanied by one-sided tearing and nasal congestion, and often triggered by occasional wine or chocolate. The muscle cramps mainly affected the legs and seemed to worsen after exercise.

When I got the results of his lab work, I was surprised to see an elevated muscle enzyme level (creatine phosphokinase or CPK). When I called my patient with the result, he admitted that he had been taking creatine supplements a few times a week to improve his workout and help him increase his weightlifting. He said the product promised that his exercise recovery time would be shortened as well, so he was willing to give it a try.

Until I saw the elevated muscle enzyme, I hadn’t thought to ask this patient about whether he was taking creatine because he had already listed the supplement combination of glucosamine and chondroitin as well as omega-3 fatty acids on his medication list.

Creatine is one of the most common dietary supplements used today among recreational exercisers like my patient. Athletes, teens, and older people make up the other highest user groups. Because the reports related to adverse side effects of creatine have mainly been anecdotal, and experts consider it “generally safe,” it didn’t make it into our list of the “dirty dozen” supplements to avoid.

But a 2009 position paper by the American College of Sports Medicine cited creatine as currently the most widely used performance enhancer among athletes wanting to build muscle and enhance recovery and acknowledged that its most common adverse effects were weight (fluid) gain, cramping, nausea, and diarrhea. Indeed, when my patient stopped using the supplement, his muscle enzymes returned to normal in about two weeks, and his cramps went away. (His headaches did too, but we weren’t sure whether the supplement played a role.)

If you’re taking a supplement, even occasionally, be sure to list it with your medications on your medical forms and tell your doctor about it. Some interact with medications that your doctor may prescribe or shouldn’t be taken with certain foods; others may be contaminated with heavy metals or pesticides that are causing your symptoms, and some are just dangerous.

Orly Avitzur is medical adviser at Consumer Reports and blogs at the Consumer Reports Health Blog.

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  • Stephen Welch

    Is the creatine really to blame?

    Although i find this anecdotal case interesting, I can’t help wonder if creatine, and indeed other supplements, are being made villains without due cause. What I’d like to see is a study that investigates how people took supplements, and determines whether they took them as directed or not. Questions could include the following:

    1. Where they adequately hydrated?
    Using supplements and working out can dehydrate people, and many weekend warriors and armchair athletes simply don’t drink enough water. This means they have depleted electrolytes, a common cause of cramping. Of course, creatine affects hydration as well, so an inadequate water intake my have enhanced the potential for electrolyte depletion, and had more to do with the patient’s cramps than the creatine itself. Ditto for the headaches, which are commonly alleviated by appropriate hydration.

    2. Where they using supplements as supplements, or were they using them as meal replacements?
    This is another common error on the part of “regular people” who exercise. They replace meals with supplements, and may not be getting enough of certain types of nutrients. This can also throw off the body’s balance.

    3. Is it possible the patient was taking other “supplements’ that were not disclosed?
    There are herbal versions of caffeine and other stimulants in a lot of supplements, and people simply don’t take their affects into consideration.

    The bottom line is that there are a lot of factors that are difficult to control for. I’ve used creatine off and on for years and never had any adverse affects. I also think that a lot of supplements can be beneficial, but only when used APPROPRIATELY. And that’s the key thing.

    People who use supplements need to take personal responsibility to ensure they take them safely and effectively. Sadly, this doesn’t happen often enough. Somebody has an adverse affect and immediately starts pointing fingers at the “dangerous supplements” when in fact they may have been taking it inappropriately or combining it with other supplements without understanding their ingredients or effects.

    Whatever happened to personal responsibility?

  • http://minochahealth.typepad.com doc

    Dr. Welch makes some excellent points.
    I would just add that while we insist on practitioners of complimentary medicine to practice evidence based medicine based on randomized controlled trials, we ourselves sometimes have no problems drawing sweeping conclusions and making generalizations from anecdotal reports.
    Individual responsibility is a must. Users of any medicine or supplement (from any source) should discuss such issues with their physician.

  • http://www.con-cret.com Mark Faulkner

    I spoke recently with several exercise enthusiasts / weight lifters who all had similar complaints of headaches, elevated blood pressure, and muscle cramps. A quick review of the ingredient list of their creatine supplement (they were all taking similar products) revealed:

    1. A high dose of creatine monohydrate…which has cramping and fluid re-distribution tendencies (vs. for example, creatine HCl which is taken in low doses and doesn’t have the same side effects)

    2. A long list of other compounds including high doses of psycho-motor stimulants and other somewhat veiled ingredients/doses that appear to be responsible for having a significant effect on both cardiovascular and neuro-chemical systems. When they “deselected” their supplements and instead chose products with reasonable and targeted and easily understood ingredients and dosing, both their performance and their side-effects experiences were improved.

    Creatine, when chosen in an effectively conjugated form and dosed properly, is very safe and VERY efficacious for strength, endurance, and recovery.

    Good luck.

  • Anon EM doc

    So you’re saying that this person was taking creatine monophosphate and their serum levels of creatine phosphokinase went up? Sounds a lot like the case of hypernatremia I developed after eating Ramen Noodles.

    Seriously though, I gotta agree with the above commenter; the conjugated creatine I take gives me far fewer side effects than monohydrate. Furthermore, I have yet to see any scientifically valid evidence that either form of creatine causes anything more than spuriously elevated lab values (certainly not any clinically significant end organ damage.

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