Comments on: Exubera linked to lung cancer? http://www.kevinmd.com/blog/2008/04/exubera-linked-to-lung-cancer.html Tue, 14 Feb 2012 17:18:00 +0000 hourly 1 By: Christine-Meganhttp://www.kevinmd.com/blog/2008/04/exubera-linked-to-lung-cancer.html#comment-84945 Christine-Megan Thu, 10 Apr 2008 15:43:00 +0000 http://clients.emmense.com/kevinmd/2008/04/exubera-linked-to-lung-cancer.html#comment-84945 Eh, I don't think it was a cover up. I think it wasn't used long term enough to fully appreciate the side effects. If they know a drug isn't fully absorbed, and they know it decreased respiratory function, malignancies do seem like a logical next step.<br/><br/>But, like you say, they were all smokers. I wonder why smokers were in the study at all, as I believe smoking was a contraindication to Exubera. Eh, I don’t think it was a cover up. I think it wasn’t used long term enough to fully appreciate the side effects. If they know a drug isn’t fully absorbed, and they know it decreased respiratory function, malignancies do seem like a logical next step.

But, like you say, they were all smokers. I wonder why smokers were in the study at all, as I believe smoking was a contraindication to Exubera.

]]> By: Matthew Mintz, MDhttp://www.kevinmd.com/blog/2008/04/exubera-linked-to-lung-cancer.html#comment-84943 Matthew Mintz, MD Thu, 10 Apr 2008 12:26:00 +0000 http://clients.emmense.com/kevinmd/2008/04/exubera-linked-to-lung-cancer.html#comment-84943 Christine,<br/>Your healthy scepticism is appreciated, but in this case I don't believe this is a big pharma cover up. According to the report, 6 out of 4,740 patients treated with the Exubera got lung cancer compared to 1 patient out of 4,292 who did not; and all seven patients had a history of smoking. This is hardly clear cut evidence of a link to lung cancer. The reason Pfizer in cooperation with the FDA volunteered to change their label was due to liability. Though they gave up their patent rights and no longer market the drug, some patients are still takaing the remaining supply of Exubera. Putting the warning in ASAP (even if the risk isn't clear) potentially protects them from future law suits, and since they are not selling the drug any more, they have nothing to lose. Christine,
Your healthy scepticism is appreciated, but in this case I don’t believe this is a big pharma cover up. According to the report, 6 out of 4,740 patients treated with the Exubera got lung cancer compared to 1 patient out of 4,292 who did not; and all seven patients had a history of smoking. This is hardly clear cut evidence of a link to lung cancer. The reason Pfizer in cooperation with the FDA volunteered to change their label was due to liability. Though they gave up their patent rights and no longer market the drug, some patients are still takaing the remaining supply of Exubera. Putting the warning in ASAP (even if the risk isn’t clear) potentially protects them from future law suits, and since they are not selling the drug any more, they have nothing to lose.

]]> By: Christine-Meganhttp://www.kevinmd.com/blog/2008/04/exubera-linked-to-lung-cancer.html#comment-84941 Christine-Megan Thu, 10 Apr 2008 06:19:00 +0000 http://clients.emmense.com/kevinmd/2008/04/exubera-linked-to-lung-cancer.html#comment-84941 Big surprise- the lungs don't like foreign particles? Color me shocked. They knew it wasn't all absorbed. They knew it caused lung damage (thought not how much). Big surprise- the lungs don’t like foreign particles? Color me shocked. They knew it wasn’t all absorbed. They knew it caused lung damage (thought not how much).

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