http://www.kevinmd.com/blog/2007/11/why-is-chlorthalidone-underused.html Tue, 14 Feb 2012 17:18:00 +0000 hourly 1 http://www.kevinmd.com/blog/2007/11/why-is-chlorthalidone-underused.html#comment-81686 Anonymous Fri, 09 Nov 2007 19:03:00 +0000 http://clients.emmense.com/kevinmd/2007/11/why-is-chlorthalidone-underused.html#comment-81686 In my experience, significant hypokalemia is more common with chlorthalidone that it is with HCTZ. This may be due to the duration of the diuretic effect. The antihypertensive effect of HCTZ appears to be of much longer duration than the diuretic effect. In my experience, significant hypokalemia is more common with chlorthalidone that it is with HCTZ. This may be due to the duration of the diuretic effect. The antihypertensive effect of HCTZ appears to be of much longer duration than the diuretic effect.

]]> http://www.kevinmd.com/blog/2007/11/why-is-chlorthalidone-underused.html#comment-81683 Louis Fri, 09 Nov 2007 17:46:00 +0000 http://clients.emmense.com/kevinmd/2007/11/why-is-chlorthalidone-underused.html#comment-81683 I've personally never used it, but I have heard that it caused much more hypokalemia than HCTZ. There's a good SERMO post from several months ago about the same topic. Let's not forget that Chlorthalidone was the thiazide diuretic that was used in the ALLHAT trial. Most probably feel that the effect seen in ALLHAT was a class-effect and not specific to just Chlorthalidone. I’ve personally never used it, but I have heard that it caused much more hypokalemia than HCTZ. There’s a good SERMO post from several months ago about the same topic. Let’s not forget that Chlorthalidone was the thiazide diuretic that was used in the ALLHAT trial. Most probably feel that the effect seen in ALLHAT was a class-effect and not specific to just Chlorthalidone.

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