Now that Pfizer’s torcetrapib was DOA, how can you raise HDL? Well, there’s plain old exercise for starters:
A regular aerobic exercise program of at least two hours a week produced a small but significant increase in HDLs, according to a meta-analysis.
Related posts:
- RIP Torcetrapib
- The NEJM as a tabloid
- Torcetrapib failed even worse than thought
- Peter Rost with an open letter to Pfizer’s CEO
- Avandia and meta-analysis
- Avandia and heart attacks
- Avandia: The NEJM is "becoming more like British tabloid newspapers"
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There is a good CCJM review on the subject which I linked in the references of this case description:
A 33-year-old man has a low HDL level. Should you treat him?
NEJM article from 2005 about how to treat low HDL.
DONT FORGET…GLASS OF WINE A DAY!!!! (my favorite)
http://content.nejm.org/cgi/content/full/353/12/1252?andorexacttitleabs=and&search_tab=articles&tocsectionid=Original+Articles&tocsectionid=Special+Reports&tocsectionid=Special+Articles&tocsectionid=Videos+in+Clinical+Medicine&tocsectionid=Clinical+PracticeAORBClinical+Therapeutics&tocsectionid=Review+ArticlesAORBClinical+PracticeAORBClinical+Implications+of+Basic+ResearchAORBMolecular+MedicineAORBClinical+TherapeuticsAORBVideos+in+Clinical+Medicine&tocsectionid=EditorialsAORBPerspectiveAORBOutlookAORBBehind+the+Research&tocsectionid=Sounding+BoardAORBClinical+Debate&tocsectionid=Clinical+Implications+of+Basic+Research&tocsectionid=Health+Policy+ReportsAORBHealth+Policy+2001AORBQuality+of+Health+Care&searchtitle=Articles&sortspec=Score+desc+PUBDATE_SORTDATE+desc&excludeflag=TWEEK_element&hits=20&where=fulltext&andorexactfulltext=and&fyear=1996&fmonth=Nov&sendit=GO&searchterm=hdl&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT
Vigorous exercise on a daily basis will raise HDL levels. However, you can’t raise HDL levels without raising total cholesterol levels too.
Most patients today are trying to keep their total cholesterol level in the normal or low range.
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