Comments on: The next Vioxx trial is on-deck http://www.kevinmd.com/blog/2006/06/next-vioxx-trial-is-on-deck.html Tue, 14 Feb 2012 17:18:00 +0000 hourly 1 By: Gasmanhttp://www.kevinmd.com/blog/2006/06/next-vioxx-trial-is-on-deck.html#comment-63776 Gasman Sun, 04 Jun 2006 15:59:00 +0000 http://clients.emmense.com/kevinmd/2006/06/the-next-vioxx-trial-is-on-deck.html#comment-63776 Show me a therapy for arthritis that improve pain and functional status that does not carry some risk. Most antirheumatics have a substantial risk of serious side effects and yet people willingly will trade a risk of death for potential improved funcion. Why should the non-steroidal class of drugs be any different? <br/><br/>The only question is not whether the drugs are a modest risk for cardiovascular outcomes, but whether the company unreasonably prevented this risk from being adequately being weighed by the the patient prior to use. Show me a therapy for arthritis that improve pain and functional status that does not carry some risk. Most antirheumatics have a substantial risk of serious side effects and yet people willingly will trade a risk of death for potential improved funcion. Why should the non-steroidal class of drugs be any different?

The only question is not whether the drugs are a modest risk for cardiovascular outcomes, but whether the company unreasonably prevented this risk from being adequately being weighed by the the patient prior to use.

]]> By: WilliamManginoMdhttp://www.kevinmd.com/blog/2006/06/next-vioxx-trial-is-on-deck.html#comment-63758 WilliamManginoMd Sat, 03 Jun 2006 22:05:00 +0000 http://clients.emmense.com/kevinmd/2006/06/the-next-vioxx-trial-is-on-deck.html#comment-63758 This is a pain management issue - and, once again - we must recognize that nonsteroidals carry a certain index associated with important side effects.<br/><br/> Forget, for now, cardiovascular risks; focus on the other side effects.<br/><br/> Mild to moderate doses of opioids should be considered in the mid-elderly with refractory pain. They are safe and not likely to cause addiction. This is a pain management issue – and, once again – we must recognize that nonsteroidals carry a certain index associated with important side effects.

Forget, for now, cardiovascular risks; focus on the other side effects.

Mild to moderate doses of opioids should be considered in the mid-elderly with refractory pain. They are safe and not likely to cause addiction.

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